Abstract We investigated an outbreak of exanthematous illness in Maceió by using molecular surveillance; 76% of samples tested positive for chikungunya virus. Genetic analysis of 23 newly generated genomes identified the East/Central/South African genotype, suggesting that this lineage has persisted since mid-2014 in Brazil and may spread in the Americas and beyond.
All research studies on human subjects should have a level of quality and ethical standard assurance built into their operations to ensure that that the rights and well-being of human subjects are protected and that the data are reliable. This combined template and guide assists research teams in developing a QA plan for their study.
This guide will set out why quality management and monitoring is important and how it can be easily and practically built into a study.
A coherent four step plan for implementing in-house or reciprocal monitoring systems at a research site
There has been a trend over recent years towards the use of expensive contract organisations to monitor research studies and this can be expensive and is not necessary. This overview explains the reasons for reciprocal monitoring, and how it can benefit research groups.
One of the goals of the REDe network is to support the conduct of high quality research by providing tools, training and guidance in all the elements that are required. A very fundamental, but often overlooked, piece in this is the planning and implementation of research quality management (which is often referred to as monitoring).
Institut Pasteur Shanghai-Chinese Academy of Sciences (IPS-CAS), a partner of the ZIKAlliance consortium, announced that it has entered into a collaborative research agreement with Chongqing Zhifei Biological Products Stock Co., Ltd. (Zhifei) for the clinical studies and commercialization of a recombinant Zika virus subunit vaccine developed by IPS-CAS.
In response to the recent World Health Organisation (WHO) Global Vector Control Response document (http://www.who.int/malaria/global-vector-control-response/en/), ARCTEC at the London School of Hygiene & Tropical Medicine is working with The Global Health Network, the WHO and the Centres for Disease Control and Prevention (CDC) to develop an exciting new initiative called The Global Vector Hub. The project is being part-funded by an EU H2020 grant as part of the recently formed ZikaPLAN consortium. We have been invited by the Wellcome Trust to submit an application for a Biomedical Resource and Technology Development Grant to help fund the website. We have successfully advanced through the first round of grant proposals. The full application is now being prepared and is due for submission on 3rd April, 2017. To demonstrate the need for the Global Vector Hub, we are collecting letters of support from potential stakeholders. It would be great if you could distribute this e-mail to your contacts and ask them to provide letters of support.
The key message from this study is that the large uncertainty around the risk estimate needs to be further investigated because of a) the possible existence of co-factors that are yet to be validated, b) the assumptions that the authors needed to make in the absence of good data for the proportion of women who were infected during pregnancy.
There has been steady progress in LMIC health research capacity, but major barriers to research persist and more empirical evidence on development strategies is required.
This pioneering study provides a precise follow-up of incident cases and seroprevalence in blood donors, and it also provides important insights into the management of blood donations during ZIKV outbreaks and into the natural history of ZIKV infection in adults. It suggests that the study of blood donors during outbreaks of emerging pathogens has become a key element of epidemiological surveillance.
A study performed by the Institut National de la Santé et de la Recherche Médicale (INSERM) team of Dr Ali Amara (U944, Paris, France) and published in Cell Reports sheds new light on the mechanisms allowing ZIKV to infect cells within the human nervous system. Amara et al. showed that the protein Axl is expressed in a number of brain glial cells and that the entry of ZIKV into these cells requires another protein, Gas6, to act as a bridge between the ZIKV particles and the glial cells.
Cochrane Crowd, Cochrane’s new citizen science platform, recently ran a successful 48 hour citation screening challenge to reach the goal of 1 million research citations screened. The Cochrane Crowd team have provided this overview of the event.
Epidemic curves are an important component of the public health and global health toolbox. Learn more about creating and interpretting them.
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