Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2'-modified nucleotide analogues

by Potisopon et al.

In addition to representing the first ZIKV full-length NS5 activity report at the molecular level, this study should help the design of pan-flavivirus drugs aiming at the control of many Flavivirus members of this large family of emerging arboviruses, as well as understand the basis of re-purposing drugs against emerging viral diseases.

21st February 2017 • comment

Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

by Coutard et al.

The results outlined in the article contribute to a better understanding of the ZIKVMTase, a central player in viral replication and host innate immune response, and lay the basis for the development of potential antiviral drugs.

21st February 2017 • comment

Zika and Other Emerging Viruses: Aiming at the Right Target

by Dallmeier & Neyts

The article argues that the off-label use of drugs that may protect against Zika virus-induced brain damage has to be balanced with their risk during pregnancy.

12th October 2016 • comment