This was a webinar led by Members of the WHO'S NeuroCOVID Forum (Dr Alessandro Padovani and Dr Lucia Brito) and Fiocruz (Dr Cristiane Bresani) to discuss the challenges and ideas to investigate cerebrovascular manifestations potentially related to COVID-19. The panellists shared their experience in the field, which includes a multicentre case-control study on the association between stroke and SARS-CoV-2 infection, run by Fiocruz in Brazil. This session was open to all who are interested in clinical research, neurology and COVID-19.